The links between TRPV4 and EMT in breast cancer have so far been indirect and include the positive correlation between an “EMT score” and TRPV4 gene expression in human breast cancer samples [18], and the ability of the non-specific TRPV4 activator 4α-PDD to reduce E-cadherin levels in mouse 4T07 mammary cancer cells [20]. This evidence concerns the gene CDH1 and breast cancer.