Genetic myostatin inhibition (i.e., through deletion or polymorphisms) results in mismatched muscle and bone growth compared to tendon and ECM development, which in higher order animals (cattle and dogs, including the GRippet (golden retriever muscular dystrophy [GRMD] crossed with the myostatin-deficient Whippet) canine model of DMD) results in joint instability and the reduced mass of many organs including lung and spleen [23,114,115]. Here, MSTN is linked to Duchenne muscular dystrophy.