APOE and atherosclerosis: We also obtained an equally significant increase in the activity of PON1, in line with what has been published by other authors who, on the one hand, saw a significant increase in the activity of paraoxonase when administering polyphenol resveratrol in mice with atherosclerosis (ApoE-deficient mice) [70], and, on the other hand, administering catechins in human beings significantly increased PON1 in serum, causing a decrease in proinflammatory cytokines [71].