IGHE and allergic asthma: Its use is recommended in adults and children (≥6 years) with moderate-to-severe chronic allergic asthma, increase total IgE levels (total IgE level of 30–700 IU/mL considered in US; total IgE level of 30–1500 IU/mL considered in EU), and allergic sensitization to at least one perennial allergen [53].