Similar effects are observed when VSMC were calcified under high-phosphate conditions, leading to α-Klotho deficiency accompanied by an increase of inorganic phosphate transporter (PIT) 1 and 2 expression—transporter proteins essential for Pi influx in VSMC—indicating an interdependency of VC and hyperphosphatemia [111,132,133]. Here, KL is linked to hyperinsulinemic hypoglycemia, familial, 4.