In humans, most tumors affected by KIT mutations [3,14] mainly show SNPs affecting Ex-11 (65% of GastroIntestinal Stromal Tumors, GISTs [3]), promoting the constitutive activation of the KIT receptor without binding to the specific ligand, and leading to uncontrolled proliferation and survival of neoplastic cells [14]. The gene discussed is KIT; the disease is gastrointestinal stromal tumor.