NTRK1 and cancer: In our previous work [25] that aimed to improve our knowledge about the genomic DNA alterations that occur in COM, many genes related to MAPK and PI3K pathways were detected from the CNA analysis, together with a wide variety of genes coding for tyrosine kinases receptors, including KIT. Interestingly, the pathway enrichment analysis revealed the enhancement of pathways specifically related to cancer proliferation, but also a significant enrichment of those related to imatinib and drug metabolism.