CHI3L1 and Motor neuron atrophy: In this study, we included two PEA panels: the “cardiovascular III” panel, which contained several markers that potentially are important for amyotrophic lateral sclerosis (ALS), for example, YKL40/CHI3L1 [21], MCP-1 [22], and CHIT1 [23]; and the “cell regulation” panel, which included C-JUN (relevant for motor neuron degeneration [24]), ARYLSULFATASE B [25], and STX6 and STX16 (related to neuronal differentiation [26]).