The surface layer protein extracted from L. acidophilus NCFM also induces the formation of ROS, which, in turn, results in induced auto-phagic death in HCT116 colon cancer cells through the suppression of the mammalian target of rapamycin (mTOR) activity and activation of the c-Jun N-terminal kinase signaling pathway [9]. Here, MTOR is linked to colonic neoplasm.