Similarly, analysis of the GLRXs and TRX systems in FRDA1 and FRDA2 fibroblast cell lines from FRDA patients showed decreased expression of TRX1 and GLRX1 when compared to their respective control fibroblasts (Figure 2), which may compromise the correct activity of key enzymes in these cells obtained from FRDA patients. Here, TXN is linked to Friedreich ataxia.