In the previous section, we showed that a reduction in antioxidant genes and proteins in FRDA may be related to the downregulation of NRF2 expression, which has previously been described in DRG of YG8R [114] and in fibroblasts from FRDA patients [122], and this is of special relevance because the NRF2-ARE signaling pathway is required for TRX and TRXRD expression [114,127,128]. The gene discussed is TXN; the disease is Friedreich ataxia.