Similarly, TLR2 is expressed on pancreatic cancer, and its activation induced by its endogenous ligands, such as pancreatic adenocarcinoma upregulated factor (PAUF), induces cell proliferation, migration and angiogenesis through the production of pro-tumorigenic cytokines, vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF) [62,63]. Here, VEGFA is linked to familial pancreatic carcinoma.