Similarly, the treatment of mice bearing human gastric cancer xenografts or of gp130F/F genetically modified mice spontaneously developing gastric cancer with anti-TLR2 monoclonal antibodies (OPN-305 or its mouse counterpart OPN-301, respectively) significantly impaired neoplastic cell proliferation and induced their apoptosis, resulting in a 2.5 reduction of tumor growth as compared to control mice. The gene discussed is SPP1; the disease is neoplasm.