In particular, F. nucleatum is enriched in Gal-GalNac expressing tumors, such as colorectal and breast cancers, where it promotes tumor progression by inducing TLR2/TLR4- and E-cadherin-dependent activation of NF-κB and Wnt pathways on cancer cells [108], by inhibiting NK and T cell activation through interaction with the T cell immunoglobulin and ITIM domain (TIGIT) inhibitory receptor [109], and by inducing TLR2-dependent Treg activation [110,111]. Here, TLR2 is linked to neoplasm.