RUNX1 and acute myeloid leukemia: Pathway analysis conducted through STRING highlighted proteins among our top AML essential genes, with enrichment in MAPK signaling (Figure 7A), JAK-STAT/PI3K-AKT signaling pathway (Figure 7B), hematopoiesis, stem cell, and hemopoiesis (Figure 7C), and RUNX1 related pathways (Figure 7D).