AKT1 and hepatocellular carcinoma: FGFs are potent angiogenic factors for hepatoma [16,17], and high expression of basic FGF has been detected in patients with HCC [18], where its activation via binding to FGFR led to downstream activation of several pathways including mitogen-activated protein kinase (MAPK) pathway and phosphoinositide-3 kinase-Akt-mTOR pathway [19].