APOE and early-onset autosomal dominant Alzheimer disease: GAAIN comprises an extensive database of 51 AD cross-sectional and longitudinal studies from across the globe, of which the Alzheimer’s Disease Repository Without Borders (ARWIBO), the Kame Project (KAME), Arizona APOE4 Gene Dose Program (APOE4), and Long Beach Longitudinal Study (LPLS) datasets were utilized for this study to investigate the effects of NSAIDs on cognition status.