Chronic treatment with the RyR modulator dantrolene has been shown to restore PTP and LTP to control levels seen in non-AD mice, and this effect was accompanied by a restoration of presynaptic vesicles in the active zone, illustrating a role for aberrant presynaptic RyR-Ca2+ signaling in the impaired short and long-term synaptic plasticity observed in AD mice [8]. Here, RYR2 is linked to Alzheimer disease.