In particular, the RyR2 isoform, which is overexpressed in the hippocampus of AD mice [30,114], plays an important role in maintenance of synaptic function [128] and shortening of the RyR2 mean channel open time reverses the synaptic dysfunction and Ca2+ dyshomeostasis observed in an AD mouse model [47]. The gene discussed is RYR2; the disease is Alzheimer disease.