Along this line, higher expression of CaIX, Phd3, Slc7a5, Glut1, Pgm1 occurred but not Ndrg1 in a Vhl-deficient renal cell mouse model when compared with non-tumor renal region, which is in line with our data in Vhl-deficient kidneys [47]. The gene discussed is CA9; the disease is neoplasm.