Reports have suggested that Cx43 inhibits basaloid carcinoma cell proliferation through a cytoplasmic role [66], colorectal cancer cell proliferation through an effect on the WNT/β-catenin pathway independent of GJIC [67], glioma cell proliferation by decreasing the activity of SRC through interaction with the Cx43 C-terminal tail [68,69], epidermal growth factor (EGF)-induced ovarian cancer cell proliferation [70], and neuroblastoma cell proliferation [71], among others. Here, GJA1 is linked to central nervous system cancer.