In 2012, Rocca and coworkers displayed for the first time that NK cells infiltrating human CRC tissue displayed a profound alteration of their phenotype with a drastic reduction of different NK cell receptor expression, including NKp46 and NKp30, with respect to NK cells infiltrating normal mucosa and NK circulating in PB derived from the same donors [100]. Here, NCR3 is linked to colorectal carcinoma.