TP53 and osteosarcoma: In another study, a subtoxic dose (5 μM) of fucoxanthin demonstrated anti-invasive and anti-metastatic potential by decreasing the levels of stemness-related proteins (Wnt-1 and β-catenin), EMT markers (fibronectin, MMP-2, and vimentin), and an angiogenic factor (VEGF) in p53 wild-type U2OS osteosarcoma and p53 null SKOV3 ovarian cancer cells [102].