The anti-metastatic effect of lycopene was also observed through the down-regulated expression of ITGA5 and ITGB1 [91], key players in ovarian cancer cell invasion and metastasis [92], MMP-9, and EMT markers (TWIST, ZEB2, SNAI-1 and -2, FOXC2, FN1, TGFB-1 and -2, TGFBR1, and SMAD4) in OV-MZ-6 ovarian cancer cells [91]. This evidence concerns the gene SMAD4 and ovarian cancer.