Fu et al. [21] observed a marked translocation of HMGB1 in hippocampal and cerebral cortex neurons after systemic injections of pilocarpine and a remarkable inhibition of HMGB1 translocation by systemic injections of anti-HMGB1 mAb, leading to the suppression of status epilepticus. The gene discussed is HMGB1; the disease is status epilepticus.