In both analyses, we confirmed many of the previously reported CAD associated loci at genome-wide significance (P≤5×10-8), including SORT1/CELSR2, WDR12, PHACTR1, TCF21, 9p21.3, CXCL12, and ADAMTS7. We selected 142 variants that achieved P≤5×10-4 in either the unadjusted or the T2D- adjusted analyses for replication analyses. The gene discussed is PHACTR1; the disease is coronary artery disorder.