Few variants have been associated with both CAD and T2D: a variant near IRS1 was associated with both diseases at genome-wide significance (P≤5×10-8) and 8 other loci at a lower significance level.9 Given that there are few variants jointly associated with CAD and T2D, it is unsurprising that there is sparse evidence for overlapping pathways contributing to both diseases.10 Here, IRS1 is linked to type 2 diabetes mellitus.