In addition, 4HR downregulated the expression of oncogenesis-related proteins, i.e., a negative regulator of apoptosis (survivin, 14.8% at 8 h), an anti-adhesive glycoprotein that contributes to tumor development and metastasis (mucin 4, 5.7% at 24 h), and a potent oncogene that binds to 14-3-3 (YAP, 20.6% at 8 h). Here, CD226 is linked to neoplasm.