The overexpression of growth factors (TGF-βs, HGFα, IGF-1, and HER1), cell survival proteins (TERT, SP-1, and PGC-1α), M2 macrophage polarization proteins (IL-10, M-CSF, Pdcd-1/1, and COX-2), and angiogenesis-related proteins (VEGF-A, VEGF-C, and vWF) may be critical to tumor recurrence and metastasis. The gene discussed is SP1; the disease is neoplasm.