MC1R and skin neoplasm: In the analysis of skin cancer in the UK Biobank, three melanin or melanogenesis-related genes (TYR, OCA2, and MC1R) and telomerase reverse transcriptase (TERT) were top-ranked by the omnibus test, but not top-ranked based on TSS-to-top-SNP distance, while all other benchmark genes for skin cancer were top-ranked by both methods or by neither.