Later time-point disease monitoring revealed that, compared with isotype-treated mice, anti–PD-1–treated mice had lower sepsis scores after infection (Figure 6F) and a reduced bacterial load in the liver, spleen, and lungs (24 h after infection, Figure 6G), as was seen in PD-1–/– mice (Figure 5, F and G). Here, PDCD1 is linked to Sepsis.