CRP and Sepsis: Compared with APAP-treated PD-1–/– mice, APAP-treated WT mice had a higher fold change of C-reactive protein (CRP) and lactate levels (Supplemental Figure 6, A and B) and a cytokine profile that favored a proinflammatory imbalance, as indicated by increased sepsis severity markers (29–31) such as IL-6 and a higher IL-6/IL-10 ratio (Supplemental Figure 6, C–F).