In contrast to APAP-treated WT mice, which had reduced KC E. coli capture and killing, APAP-treated PD-1–/– mice showed a preserved KC phagocytic capacity (Figure 5, B–E) and a lower tissue bacterial burden, suggesting a lack of systemic bacterial dissemination (20 min after infection, Supplemental Figure 1E). The gene discussed is PDCD1; the disease is infection.