To explore the kinome landscapes among the 3 molecular subtypes of GIST, we performed MIB-MS profiling on 33 IM-naive primary gastric GIST specimens, which included the following subtypes: (a) KIT exon 11 mutants (n = 15), (b) PDGFRA mutants (n = 10), and (c) KIT/PDGFRA-WT GISTs (n = 8) (Table 1). This evidence concerns the gene KIT and gastrointestinal stromal tumor.