CCND1 and gastrointestinal stromal tumor: Interestingly, the KIT-independent cell line, GIST-T1+D842V KITKO, has significantly more cyclin D1 than the KIT-dependent line, GIST-T1+Cas9, in accordance with a recent report (37), providing a potential explanation for the differential effects of MK-1775 and avapritinib in these 2 cell lines.