Remarkably, we found that different subtypes showed difference among diverse ECM sites, which is probably because different subtypes have different genetic variation propensities, such as EGFR, ALK, and MET were seen more mutated in AD, while FGFR1 and FGFR3 mutation were more frequent in SCC.28, 29, 30, 31, 32. Here, ALK is linked to Alzheimer disease.