GWAS studies have found linkages between schizophrenia and a variety of glutamate receptors, including GRIN2A which encodes for the NMDAR–NR2A subtype [107] Rare de novo mutations linked to schizophrenia also include proteins that are part of the NMDAR complex, including loss-of-function mutations in DLG2 [108], a PSD protein that anchors NMDAR–NR2B into the synapse [109]. This evidence concerns the gene DLG2 and schizophrenia.