RYR2 and psychiatric disorder: It is also of interest that de novo mutations in the internal calcium channel, RyR types 3 or 2, are associated with increased risk of adult-onset [108] or child-onset [113] schizophrenia, respectively, suggesting that mutations that bring excessive amounts of calcium into the neuron (CACNA1C), or those that alter internal calcium release (RYR2, RYR3), confer risk for mental illness.