It is also of interest that de novo mutations in the internal calcium channel, RyR types 3 or 2, are associated with increased risk of adult-onset [108] or child-onset [113] schizophrenia, respectively, suggesting that mutations that bring excessive amounts of calcium into the neuron (CACNA1C), or those that alter internal calcium release (RYR2, RYR3), confer risk for mental illness. This evidence concerns the gene RYR2 and schizophrenia.