CD40 and acute kidney injury: The proportion of CD11+ DC (gated on CD45+Lin− cells) and their maturation status (CD80, CD86, CD40 expression) was unchanged in the kidney regardless of treatment, however CD11c+103+ DC, which have been implicated in acute tubular injury39, was increased in colchicine-treated kidneys following AKI (Fig. 4C), but decreased in the spleen.