TARDBP and amyotrophic lateral sclerosis: Likewise, in ALS, the normally nuclear RNA-binding proteins, TDP-43 and FUS, accumulate in toxic oligomeric structures and cytoplasmic inclusions in different forms of disease (Gitler and Shorter, 2011; Johnson et al., 2009; Ling et al., 2013; March et al., 2016; Sun et al., 2011).