SLC6A3 and Parkinson disease: To test whether TtHsp104, and TlHsp104, which selectively suppress αSyn toxicity in yeast, would likewise suppress αSyn toxicity in animals, we turned to a C. elegans model of Parkinson’s disease in which the dopamine transporter (dat-1) promoter is used to direct expression of αSyn to dopaminergic (DA) neurons (Cao et al., 2005).