Autoimmune diseases including Sjogren's syndrome (SS), rheumatoid arthritis (RA), SLE, and hyperthyroidism are confirmed in all of the NMOSD patients, and 28.85% ANA (+) patients are diagnosed with SS, which have a significantly higher incidence than ANA (−) patients (28.85% versus 4.40%, p = .001). This evidence concerns the gene BTG3 and autoimmune disease.