TRPM6 and magnesium deficiency: In these, we want to underline the crucial role of TRPM6, the principal factor involved in magnesium reabsorption, in fetal development and postnatal life [18]; the ability of gestational magnesium deficiency to interfere with the fetal growth and development [47]; and the consequences of maternal magnesium deficiency during pregnancy on health status at birth in childhood and adulthood [49] (Fig. 1).