According to the amyloid hypothesis for AD, generation and aggregation of beta-amyloid peptide (Aβ) represent the initiator and main factor in a cascade of events which include oxidative stress, synaptic dysfunction, mitochondrial dysfunction, and hyperphosphorylation of Tau protein (pTau) leading to neurodegeneration [25, 39, 45]. This evidence concerns the gene MAPT and Alzheimer disease.