PPARδ could increase endothelial nitric oxide synthase (eNOS) production by activating phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) or 5′ adenosine monophosphate-activated protein kinase (AMPK) signaling pathway in renal arterial endothelium of spontaneous hypertension rats [26]. Here, NOS3 is linked to hypertensive disorder.