RORC and melanoma: Compared to the TOR-KI compound Torin-1, SBI-756 (1 μM or lower concentration) did not inhibit phosphorylation of mTORC1 or mTORC2 substrates in melanoma cells.19 To test whether SBI-756 alters mTOR activity in lymphoma cells, we measured mTORC1 and mTORC2 substrate phosphorylation.