BIRC5 and cancer: Chemical inhibition of mTORC1 or eIF4F in cancer cells selectively suppresses translation of mRNAs with specific features in the 5′ untranslated region (UTR).37 These eIF4F-sensitive mRNAs include several that encode prosurvival proteins, including MCL-1, BCL-xL and survivin.18 To determine whether SBI-756 affects expression of these factors in DLBCL cells, we measured expression of candidate proteins by western blot.