Comparing mean concentrations, significant differences were found between AD LS and healthy control skin for IL-1α, IL-1β, IL-18, CCL17, CCL22, CCL27, CXCL8, CXCL10, TNF-α, TSLP, VEGFA and (corrected p-value < 0.001) (Table 3). The gene discussed is CCL22; the disease is Alzheimer disease.