Recurrent variants (p.R119Q and p.R131C of ROBO1 and p.R462C, p.A340T, p.P322L, p.R461C, p.R388W, p.R420W, and p.G576R of SLIT2) found that implies the pathogenic significance of the variants across tumour types. The gene discussed is SLIT2; the disease is neoplasm.