However, 2 variants of ROBO1.IG1, 2 variants of SLIT2.D2 and 1 variant of ROBO4.IG1-2 domains in lung cancer dataset and 6 variants in SLIT2.D2 in the non-lung cancer dataset exhibits an intra-orbit amino acid position shift compared to wild types. Here, ROBO1 is linked to lung cancer.