Since Sarm1 expression is restricted to neurons and immune cells25, it is possible that the rapid calpain activation that is required for DNA-platinum adduct formation, and therefore neurotoxicity, with CDDP is dependent on Sarm1 activation and that selective expression of Sarm1 is responsible for the differential effects of Sarm1 in neurons versus cancer cells. This evidence concerns the gene SARM1 and cancer.