In terms of lifetime risk for breast cancer by age 80, women with the PALB2 mutation and average PRS (10–90th percentile) had a lifetime risk of 55.3% (95% CI 49.4–61.2%), which increased to 83.9% (71.2–96.6%) among women with a high PRS (>90th percentile), and decreased to 49.1% (30.6–67.6%) in women with a low PRS (<10th percentile; Fig. 2 and Tables 3 and 4). The gene discussed is PALB2; the disease is breast carcinoma.