We also observed that although silencing of PA28α did not induce autophagy, which is active in these cells, however, it did upregulate p62/SQSTM1 protein levels (Fig. 7d) which could protect cells under proteasome deficiency by enhancing the delivery of ubiquitinated proteins to the autophagy pathway. Here, SQSTM1 is linked to hyperinsulinemic hypoglycemia, familial, 4.