We also observed that although silencing of PA28α did not induce autophagy, which is active in these cells, however, it did upregulate p62/SQSTM1 protein levels (Fig. 7d) which could protect cells under proteasome deficiency by enhancing the delivery of ubiquitinated proteins to the autophagy pathway. The gene discussed is PSME1; the disease is hyperinsulinemic hypoglycemia, familial, 4.