Interestingly, our in vitro data we demonstrated that radioresistant phenotype observed under hypoxic conditions was abrogated with both JmjC-KDMs activity inhibition and KDM3A-KD, promoting radiosensitization in ESCC cells, in line with the results obtained with IOX1 inhibitor. The gene discussed is KDM3A; the disease is esophageal squamous cell carcinoma.