KDM3A and esophageal squamous cell carcinoma: In tissue samples, nuclear KDM3A protein expression was significantly higher in ESCC than in normal esophagus (NE) (67% vs 5%, p < 0.0001), whereas no differences were apparent concerning KDM6B expression (42% vs 20%, p = 0.019) (Fig. 7a, b and Table 1).