To test this hypothesis, we detected the expression of miR-21 and VMP1 in different CRC cells, and found that miR-21 expression was negatively correlated with the expression of VMP1, the expression of VMP1 in miR-21 deficient cells (RKO-miR-21-KO) was much higher than that in parental RKO cells (Fig. 1e). This evidence concerns the gene VMP1 and colorectal carcinoma.