Analysis of data from the Kaplan–Meier Plotter database26 showed that the overall survival rate of HNSCC patients (n = 519) with high expression of FN1 (n = 158) was significantly lower than that of HNSCC patients with low expression of FN1 (n = 341) (Fig. 1c). This evidence concerns the gene FN1 and head and neck squamous cell carcinoma.