SRY and Timothy syndrome: The karyotype 45,X/46,X,idic(Y) is rarely detected prenatally and the phenotypes of these patients, ranging from TS to sexual developmental disorder, sex ambiguity to azoospermia, and mental retardation, may be influenced by the location of Y chromosome breakpoints, the proportion of abnormal cell lines, and whether the SRY gene is lost [43–45].