The female ovarian function maintenance region is primarily located at Xp11 and Xq13-q26, while deletion in Xq28 can cause premature ovarian failure and infertility, of which, the involved genes POF1 and POF2 are located in Xq26-q28 and Xq13.3, respectively [37]. This evidence concerns the gene FMR1 and primary ovarian failure.