In this study, it was identified as a pan AC discriminative gene, which leads us to anticipate that PVT1 may be more relevant to the AC type than the SCC type, even though PVT1 has also been verified in the literature to associate with the SCC cancer type such as esophageal squamous cell carcinoma [124]. Here, PVT1 is linked to esophageal squamous cell carcinoma.