Given that GRM4 and SSTR2 were significantly higher in the BRCA samples than in the normal samples, in addition to the enrichment of GTPase binding molecular function, cAMP, PI3K-Akt, and MAPK signaling pathways in the co-expression Brown module, our results suggested that GRM4 and SSTR2 play a vital role in BRCA metastasis and prognosis by regulating these pathways and may thus be used as therapeutic targets for BRCA patients. The gene discussed is GRM4; the disease is invasive breast carcinoma.