WWTR1 and neoplasm: To explore the function of adipocytic TAZ tumor regulation in vivo, we generated adipocytic TAZ knockout mice (TAZ AKO) by crossing TAZflox mice with mice expressing cre recombinase under the control of the adiponectin gene promoter (Adiponectin-cre; TAZflox/flox), then performed tumor transplant assays (Fig. 3A).