Critically, we observed no obvious influence of adipocytic TAZ knockdown on adipocyte differentiation measured by Oil-Red O staining and perilipin 1 expression (SI Appendix, Fig. S4D) or breast cancer cell toxicity in the CM system measured by CCK assay (SI Appendix, Fig. S4E), ruling out the effects of adipogenesis and breast cancer apoptosis. Here, WWTR1 is linked to breast carcinoma.