WWTR1 and cancer: In addition to facilitating proliferation, adipocytes also promote cancer cell stemness (6); we further interrogated adipocytic TAZ in cancer stemness maintenance by mammosphere formation assay, a surrogate marker of stem cell self-renewal, and found that Adipo-CM increased mammosphere formation in E0771 cells, which was reduced by adipocytic TAZ knockdown both from sphere number and diameter (Fig. 2 D and E).