WWTR1 and neoplasm: Compared to 3T3-L1 fibroblast-CM (Fibro-CM), Adipo-CM significantly increased E0771 and 4T1 cell proliferation as measured by EdU incorporation assay, crystal violet staining, and intracellular ATP levels, while TAZ knockdown–Adipo-CM diminished the tumor-promoting effects (Fig. 2 B and C and SI Appendix, Fig. S4 A–C).