Among the patients in our study, the Clinical Frailty Scale (CFS) score (OR 1.50, 95% CI 1.24 to 1.83, p<0.001), peripheral artery disease (PAD; OR 2.34, 95% CI 1.32 to 4.13, p=0.003), serum albumin concentration <3.5 g/dL (OR 2.15, 95% CI 1.25 to 3.68, p=0.006), LVEF (OR 0.96, 95% CI 0.94 to 0.97, p<0.001) and preoperative moderate or severe MR (OR 2.60, 95% CI 1.42 to 4.74, p=0.002) were identified by the multivariate logistic regression analysis as predictors for the need for Em-TAVR (table 3). This evidence concerns the gene ALB and miotic rate.