TGFBR1 and posterior cortical atrophy: Finally, several signaling molecules with known roles in PCa were upregulated, such as the transcription factor Yin Yang 1 (YY1) [65], the TGF-β receptor TGFBR1 [66], and KPNA4, which promotes metastasis through activation of NF-κB and Notch signaling [67].