ACP3 and posterior cortical atrophy: We utilized two independent PCa cohorts (TCGA [8] and MSKCC [31]) to validate the potential effects of those five genes: we computed the association between the CNAs of each significant regulator and the corresponding mRNA log-FC of ACPP in each cohort and confirmed that the signs of the effects (i.e., effect directions) were the same for all five genes in all cohorts.