Extracellular macromolecules correlated with cell necrosis are more plentiful in breast cancer, especially in tumors with high Ki-67 levels, than in noncancerous tissue, and the more abundant the extracellular matrix, the longer the T1 relaxation time will be, which may be the reason for the increased T1 value in breast cancer compared to benign lesions. The gene discussed is MKI67; the disease is breast cancer.