And we also found DHT-treated CAFs-derived exosomes decreased the expression of other proteins including Vimentin, N-cadherin, MMP-2, MMP-9, ZEB1, Snail, Slug, Twist1 in PCa cells than the control group; however, exosomes isolated from ETOH-treated CAFs increased the expression of those markers in PCa cells than that in the DHT-treated CAF Exo group (Fig. 2e-j). This evidence concerns the gene MMP9 and posterior cortical atrophy.