A previous analysis suggested that a higher baseline and increase in absolute lymphocyte counts (ALC) and absolute eosinophil counts (AEC) after ICI treatment were strongly associated with the development of irAEs in patients with solid tumors (including lung cancer, kidney cancer, melanoma, etc.)treated with anti-PD-1 antibodies (baseline ALC > 2000, AEC ≥ 100) [21]. This evidence concerns the gene PDCD1 and melanoma.