CXCL9/10/11, involved in the establishment of the CXCL9/10/11-CXCR3 axis in the tumor microenvironment, is a chemokine that activates T cells [23], which could regulate the differentiation, activation and migration of immune cells and effectively inhibit tumor growth [53] (Fig. 1b). The gene discussed is CXCR3; the disease is neoplasm.